hageman factor การใช้

• Ratnoff named the missing substance Hageman trait or Hageman factor.
• Endotoxin activates the Hageman factor ( clotting factor XII ), which causes disseminated intravascular coagulation ( DIC ).
• Ratnoff later found that the Hageman factor deficiency is an autosomal recessive disorder, after examining several related people who had the deficiency.
• Hageman factor, now known as factor XII, was identified in 1955 in an asymptomatic patient with a prolonged bleeding time named of John Hageman.
• As other clotting factors had been discovered by the time of Ratnoff's encounter with his patient, Hageman factor became known as factor XII.
• Hageman factor was first discovered in 1955 when a routine preoperative blood sample of the 37-year-old railroad brakeman John Hageman ( 1918 ) was found to have prolonged clotting time in test tubes, even though he had no hemorrhagic symptoms.
• Upon binding to clots, or to the cell surface, plasminogen adopts an open form that can be converted into active plasmin by a variety of enzymes, including tissue plasminogen activator ( tPA ), urokinase plasminogen activator ( uPA ), kallikrein, and factor XII ( Hageman factor ).
• Development of the modern technique for human blood transfusion using a cannula to connect blood vessels; first large-scale medical research project on humans in a study linking iodine with goiter prevention; pioneering use of drinking water chlorination; discovery of the cause of ptomaine food poisoning and development of serum against it and similar poisons; first surgical treatments of coronary artery disease; discovery of early treatment of strep throat infections to prevent rheumatic fever; development of an early heart-lung machine to be used during open-heart surgery; discovery of the Hageman factor in blood clotting, a major discovery in blood coagulation research; first description of how staphylococcus infections are transmitted, leading to required hand-washing between patients in infant nurseries; first description of what was later named Reye's syndrome; research leading to FDA approval of clozapine, the most advanced treatment for schizophrenia in 40 years at the time; discovery of the gene for osteoarthritis; and creation with Athersys, Inc ., of the world's first human artificial chromosome.